Accession Number : AD0448388


Title :   THE INFLUENCE OF INORGANIC SALTS ON PLASMA ANTITHROMBIN ACTIVITY,


Corporate Author : TORONTO UNIV (ONTARIO)


Personal Author(s) : Monkhouse, Frank C


Report Date : 21 Dec 1962


Pagination or Media Count : 9


Abstract : A study has been made of factors influencing the activities of plasma antithrombin. Optimal antithrombin activity was obtained between pH 7.8 and 8.5. Dialysis against distilled water reduced the antithrombin activity to less than 30 per cent of normal. The antithrombin activity was restored by the addition, directly or by dialysis, of a number of salts. The increased activity in the presence of the salts seemed to be a function of the polyvalent anions rather than of the ionic strength of the medium. The antithrombin activity of alphatocopherol phosphate in vitro appears to be a function of the phosphate ion and not of the vitamin itself. (Author)


Descriptors :   THROMBIN , METABOLISM , PH FACTOR , FIBRINOGEN , PHOSPHATES , IONS


Distribution Statement : APPROVED FOR PUBLIC RELEASE