Accession Number : AD0444589


Title :   EFFECTS OF SINGLE AND REPEATED EXPOSURES TO OXYGEN AT HIGH PRESSURE ON NORMAL RATS,


Corporate Author : UNIVERSITY OF WESTERN ONTARIO LONDON


Personal Author(s) : Patel,Yezdi J ; Gowdey,C W


Report Date : 03 Oct 1963


Pagination or Media Count : 20


Abstract : Unanesthetized rats were exposed to oxygen at high pressure (OHP)-60 lb/sq. inch gauge pressure until three convulsions had occurred. Electroencephalographic (EEG) frequency decreased and amplitude increased just before and after a convulsion; heart rate decrease and respiratory rate increasedlsio. After stage-decompression stage in about 11 minutes; heart rate returned within 32 minutes, but the respiratory rate fell below precompression levels and did not recover for some 79 minutes. Repeated exposures to OHP at weekly intervals led to a decrease in the time to the first convulsion in one series of experiments but these rats were found to have elevated respiratory rates, marked pulmonary damage, and increased Hb and erythrocytes. In a second series no change in convulsion time was noted over six weekly exposures; these animals had minimal lung pathology and showed no change in the blood picture. An increase in time to the first convulsion was noted in the group exposed repeatedly to CO2-OHP. (Author)


Descriptors :   *TOXICITY , PHYSIOLOGY , OXYGEN , HYPERBARIC CONDITIONS , SCIENTIFIC RESEARCH , LABORATORY ANIMALS , RATS , ELECTROENCEPHALOGRAPHY , CONVULSIVE DISORDERS , RESPIRATION , SURVIVAL(PERSONNEL)


Distribution Statement : APPROVED FOR PUBLIC RELEASE