Accession Number : AD0443999


Title :   PIPERIDINE DERIVATIVES WITH A SULFUR-CONTAINING FUNCTION IN THE 4-POSITION,


Corporate Author : NEW HAMPSHIRE UNIV DURHAM


Personal Author(s) : Barrera, H ; Lyle, R E


Report Date : 06 Jun 1961


Pagination or Media Count : 2


Abstract : The reaction of hydrogen sulfide with the gemdiol, 1-methyl-4-piperidone hydrochloride hydrate in isopropyl alcohol led to a good yield of a salt the properties of which showed it to be the desired 1-methyl-4, 4-dimercaptopiperidine hydrochloride (IV). The gem-dithiol IV was very reactive, for it was converted to the trithiolane on attempted recrystallization from alcohols and eliminated hydrogen sulfide on dissolution in water. A remarkable reaction was observed on treatment of the base 1-methyl-4-dimercaptopiperidine hydrate. The preparation of piperidines substituted in the 4-position with sulfur-containing functional groups requires an indirect route for synthesis. The most satisfactory preparation for 1-methyl-4-mercaptopiperidine has been shown to be through the gem-dithiol. (Author)


Descriptors :   *RADIOPROTECTIVE AGENTS , *PIPERIDINES , *THIOLS , SYNTHESIS(CHEMISTRY) , SYNTHESIS(CHEMISTRY) , SYNTHESIS , MOLECULAR STRUCTURE , INFRARED SPECTRA , HYDRATES , HYDROGEN COMPOUNDS , CHLORIDES , KETONES


Distribution Statement : APPROVED FOR PUBLIC RELEASE