Accession Number : AD0443673


Title :   BOTULINUM TOXOIDS


Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD


Personal Author(s) : Cardella, Matteo A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/443673.pdf


Report Date : Jun 1964


Pagination or Media Count : 30


Abstract : Procedures were developed for preparing purified aluminum-phosphate-absorbed, univalent, bivalent, and pentavalent botulinum toxoids to immunize man. All preparations were well tolerated and elicited satisfactory antitoxin responses in man, whether administered as a single antigen or in combination. Four separate pentavalent Type ABCDE toxoids produced immune responses to each antigen in a considerable proportion of individuals following an initial series of three injections. A booster injection administered one year after the initial injection markedly increased the antitoxin titers, and measurable antitoxin titers were found in 86 to 100% of the individuals immunized. The toxoids were antigenic for mice, guinea pigs, and rabbits. In guinea pigs the toxoids afforded a high level of resistance to challenge with toxins administered by various routes.


Descriptors :   *TOXICITY , *CLOSTRIDIUM BOTULINUM , PREPARATION , PURIFICATION , MICE , IMMUNITY , LETHAL DOSAGE , VACCINES , BACTERIAL TOXINS , RABBITS , GUINEA PIGS


Subject Categories : Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE