Accession Number : AD0443546


Title :   OBSERVATIONS ON MODE OF ACTION OF ENDOTOXIN IN CHICK EMBRYOS


Corporate Author : WALTER REED ARMY INST OF RESEARCH WASHINGTON DC


Personal Author(s) : Finkelstein, Richard A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/443546.pdf


Report Date : 18 Nov 1963


Pagination or Media Count : 9


Abstract : The preu uonfirmed the previous observation of Smith and Thomas that the chick embryo becomes refractory to intravenously administered endotoxin during the period frum the 11th to the 15th day of incubation. The magnitude of the change in susceptibility is greater than 10,000fold. Catecholamines could not be implicated in the lethal action of endotoxin in the chick embryo. Histamine, serotonin and acetylcholine were not highly toxic for the endotoxin- susceptible embryos. An anticoagulant heparin, did not protect against endotoxin, which caused capillary stasis and perivascular hemorrhage in the embryos. Natural antibody against Vibrio cholerae endotoxin could not be detected in the blood during the embryonic state. A marked hypoglycemia resulted following administration of endotoxin and insulin in the younger embryos after a slight delay in the former case.


Descriptors :   *EMBRYOS , *ENDOTOXINS , *EMBRYONATED EGG TECHNIQUE , CONTROL , REPRINTS , LETHAL DOSAGE , GLUCOSE , BIOASSAY , SHOCK THERAPY , HYPOGLYCEMIA , VIBRIO , INSULIN , MEDICAL EXAMINATION , CHOLERA , BLOOD , CHEMICAL REACTIONS , CHICKENS


Subject Categories : Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE