Accession Number : AD0442693


Title :   EFFECTS OF CHRONIC HYPOTHALAMIC LESIONS ON DIURNAL AND STRESS CORTICOSTEROID LEVELS,


Corporate Author : CALIFORNIA UNIV LOS ANGELES


Personal Author(s) : Slusher,Margaret A


Report Date : 05 Aug 1963


Pagination or Media Count : 4


Abstract : The effect of chronic lesions on plasma corticosteroid levels has been assessed in an attempt to differentiate neuronal areas affecting diurnal corticosteroid rise from those involved in acute response to stress. In unanesthetized, unrestrained rats blood samples were collected through a chronic indwelling catheter on each of four experimental days at 9 and 10 am and 5 pm with or without addition of a stress applied at 9:45 am. Anterior hypothalamic lesions bilaterally destroying the periventricular zone and arcuate nuclei were associated with inhibition of the normal 5 pm rise but with normal rise in plasma corticosteroid levels in response to sound or to a 1-min electrical stimulation of the posterior diencephalon. (Author)


Descriptors :   *DIURNAL VARIATIONS , CORTICOSTEROID AGENTS , BLOOD PLASMA , PITUITARY GLAND , STRESS(PHYSIOLOGY) , RATS , THALAMUS , STIMULATION(PHYSIOLOGY) , WOUNDS AND INJURIES


Distribution Statement : APPROVED FOR PUBLIC RELEASE