Accession Number : AD0440362


Title :   A COMPARISON OF THE ANALGETIC POTENCIES OF MORPHINE, PENTAZOCINE, AND A MIXTURE OF METHAMPHETAMINE AND PENTAZOCINE IN THE RAT,


Corporate Author : ARMY MEDICAL RESEARCH LAB FORT KNOX KY


Personal Author(s) : Evans, Wayne O ; Bergner, Donald P


Report Date : 27 Feb 1964


Pagination or Media Count : 7


Abstract : These studies were done to determine if the flinch-jump animal analgesiometric method could detect the analgetic effects of pentazocine. Also, to determine if a synergism of analgetic activity could be produced by adding methamphetamine to pentazocine. The flinch-jump procedure showed pentazocine to be an analgesic with a potency about one-third to one-quarter as great as morphine. Methamphetamine in combination with pentazocine raised the potency by a synergistic action. It was suggested that the combination of methamphetamine and pentazocine might have the following properties: (1) non-addicting, (2) a good analgetic potency, (3) little autonomic depression, and (4) no sedation. (Author)


Descriptors :   *ANALGESICS , ANTIPYRETICS , RATS , MORPHINE , AMPHETAMINES , PHARMACOLOGY , PSYCHOLOGY , BEHAVIOR , AUTONOMIC NERVOUS SYSTEM


Distribution Statement : APPROVED FOR PUBLIC RELEASE