Accession Number : AD0439309


Title :   EXPLORATION OF NEW CHEMOTHERAPEUTICS FOR INFECTIOUS DISEASES


Descriptive Note : Semi-annual rept., 20 Mar-19 Sep 1963


Corporate Author : KITASATO INST TOKYO (JAPAN)


Personal Author(s) : Hata, Toju


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/439309.pdf


Report Date : 19 Sep 1963


Pagination or Media Count : 6


Abstract : Protomycin, a new antiamaebic substance was producted by a new strain Sterptomyces reticuli var. protomycicus, was determined chemical properties and structure. Next subjects are planted the mass production of Protonycin, subsequently treated amaebic patients with it. As a new other antibacterial and antifungal susstance was fund in this Streptomyces cultural media the substance was tried to purify and crystallize at the present time. Finally a antibacterial substance was crystallized as a colorless needle crystaline substance. Antimicrobial activity of this crystaline substance: The minimal inhibitory concentration of the substance was 1 mcg/ml - 1,000 mcg/ml to gram positive bacteria, but this dis not show inhibitory effects to gram negative bacteria.


Descriptors :   *CHEMOTHERAPEUTIC AGENTS , CHEMICAL PROPERTIES , DISEASES , STREPTOMYCES , JAPANESE B ENCEPHALITIS VIRUS , JAPAN , PATHOLOGY , INFECTIOUS DISEASES


Subject Categories : Anatomy and Physiology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE