Accession Number : AD0437605


Title :   STUDIES OF ABSORPTION-TRANSPORT MECHANISMS IN THE SMALL INTESTINE.


Descriptive Note : Annual progress rept., 1 Aug 63-31 July 64,


Corporate Author : MIAMI UNIV CORAL GABLES FL SCHOOL OF MEDICINE


Personal Author(s) : Nunn, Arthur S , Jr


Report Date : 31 Jul 1964


Pagination or Media Count : 35


Abstract : Studies concerning the mechanisms of intestinal glucose absorption indicate that the monophosphoesterases are not distributed along the intestinal length in a pattern which would directly involve them in the absorption process. The kinetics of these phosphatases indicate support for the concept that phosphorylation of glucose is not involved in its transport across the mucosa. The oxygen utilization by in vitro intestinal segments during glucose transport indicates a dependency upon .lycolytic pathways for theincreased energy requirements. Indirect evidence of non-oxidative phosphorylation of ADP to ATP has been presented and has been postulated as the possible rate limiting step in the transport scheme. Ouabain, at concentrations selected to interfere selectively with the sodium pump, reduces glucose absorption but does not alter the oxidative requirements of the absorbing in vitro preparation. (Author)


Descriptors :   *INTESTINES , BIOLOGICAL ABSORPTION , GLUCOSE , TRANSFERASES , PHOSPHORYLATION , OXYGEN , GLYCOLYSIS , ADENOSINE PHOSPHATES , REDUCTION(CHEMISTRY) , SODIUM , TISSUES(BIOLOGY) , MEMBRANES(BIOLOGY)


Distribution Statement : APPROVED FOR PUBLIC RELEASE