Accession Number : AD0437510


Title :   NEW METHODS DEVELOPMENT FOR IRRITANT SCREENING.


Descriptive Note : Quarterly progress rept. no. 4, 23 Dec 6322 Mar 64,


Corporate Author : BIONETICS RESEARCH LABS INC FALLS CHURCH VA


Personal Author(s) : Ross Hart,E


Report Date : 15 Apr 1964


Pagination or Media Count : 10


Abstract : Histamine liberation appears of questionable value for prediction of irritant potency. The effects of irritants on excised tissue are being studied. A survey of suitable test species (cats, Rhesus monkeys and African green monkeys) is in progress. Screening of new compounds has been slowed due to difficulties with the quality of animal supplt; approximately 330 compounds have been studied. (Author)


Descriptors :   *IRRITATING AGENTS , LABORATORY ANIMALS , CATS , MONKEYS , HISTAMINE


Distribution Statement : APPROVED FOR PUBLIC RELEASE