Accession Number : AD0436554


Title :   GENETIC, SEROLOGIC, AND BIOCHEMICAL STUDIES ON VIRAL INFECTION AND LYSOGENIZATION.


Descriptive Note : Rept. no. 2, Final, 20 Jan 63-19 Jan 64,


Corporate Author : SAPPORO MEDICAL COLL (JAPAN)


Personal Author(s) : Uetake,Hisao


Report Date : 19 Jan 1964


Pagination or Media Count : 34


Abstract : Salmonella phage undergoes a two-way host-controlled viriation as described before. Besides multiplicity activation (MA), a thermo-labile factor responsible for phage growth restriction was found. Experiments with P32-labled phages show that the DNA of the restricted phage is degraded rapidly after injection of the nonpermissive host, and that the degradation is prevented by heating the cells prior to infection. MA-responsible, thermolabile, and DNA-destroying factors are suggested to be identical. Chemical, serological, and genetic studies have revealed the followings: Salmonella senftenberg 87Aa' with O antigen 3 alone has alpha-galactosyl-mannosylrhamnose as serological determinant; specificity 3 is determined by mannosyl-rhamnose; another cross reaction between El strains and 87Aa' is attributed to alpha-galactosyl structure; 87Aa' is suspected to carry defective prophage lacking conversion genes. (Author)


Descriptors :   SALMONELLA , GROWTH(PHYSIOLOGY) , PHOSPHORUS , GENETICS , DEOXYRIBONUCLEIC ACIDS , ANTIGENS , ANTIBODIES , BIOCHEMISTRY , INFECTIOUS DISEASES , JAPAN


Distribution Statement : APPROVED FOR PUBLIC RELEASE