Accession Number : AD0434424


Title :   ENDOCRINE AND METABOLIC EFFECTS OF SHORT-DURATION HYPEROXIA


Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TX


Personal Author(s) : Hale, Henry B ; Williams, Edgar W ; Anderson, John E ; Ellis, James P , Jr


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/434424.pdf


Report Date : Feb 1964


Pagination or Media Count : 11


Abstract : This investigation was concerned with the effects of breathing 100% oxygen (by mask) at 1 atmosphere ambient pressure for 4 hours on sympathoadrenal, adrenocortical, and metabolic functions in healthy human subjects. Control determinations were made on the same subjects on a separate occasion by having the subjects breathe room air (by mask). Sympathoadrenal activity was appraised by means of urinary epinephrine and norepinephrine determinations; adrenocortical activity was appraised by means of plasma cortisol and urinary 17-hydroxy corticosteroid determinations; and metabolic appraisal was made by means of urinary creatinine, urea, uric acid, phosphate, potassium, and sodium. Evidence of hyperoxia-induced adrenocortical and sympathoadrenal depression was found -- plasma cortisol concentration, as well as catecholamine excretion, falling below the control levels. Urine volume also was relatively low, as were urinary sodium and phosphate values. Mask discomfort was shown to be an obscuring factor, since it acted oppositely to hyperoxia in many respects. (Author)


Descriptors :   *PHYSIOLOGY , *ENDOCRINE GLANDS , *HYPEROXIA , METABOLISM , PRESSURE BREATHING , ADRENAL GLANDS , EXCRETION , ADRENAL CORTEX , EPINEPHRINE , URINARY SYSTEM


Subject Categories : Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE