Accession Number : AD0434079


Title :   EFFECT OF COLD EXPOSURE ON THE ACTION OF MORPHINE IN RATS AND MICE,


Corporate Author : CALIFORNIA UNIV LOS ANGELES


Personal Author(s) : Way,E L ; Elliott,H W


Report Date : Nov 1963


Pagination or Media Count : 24


Abstract : Data are presented showing that cold adaptation diminishes the depressant effects of morphine on respiratory minute volume, oxygen consumption and analgesia on the one hand, but enhances the toxicity of morphine on the other. Attempts to account for the difference in sensitivity between cold adapted and nonadapted animals by measuring the conjugation, excretion, and distribution of morphine in vivo, and by determining its effect on the respiration of KC1-stimulated brain slices in vitro were unsuccessful. (Author)


Descriptors :   *MORPHINE , *EXPOSURE(PHYSIOLOGY) , LABORATORY ANIMALS , LABORATORY ANIMALS , RATS , MICE , ADAPTATION(PHYSIOLOGY) , SENSITIVITY , DISTRIBUTION , TOXICITY , MEASUREMENT


Distribution Statement : APPROVED FOR PUBLIC RELEASE