Accession Number : AD0432431


Title :   INFECTIVITY AND ANTIGENICITY OF STREPTOMYCIN-DEPENDENT SALMONELLA TYPHOSA


Descriptive Note : Technical Manuscript


Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD


Personal Author(s) : Reitman, Morton


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/432431.pdf


Report Date : Feb 1964


Pagination or Media Count : 17


Abstract : A streptomycin-dependent mutant of Salmonella typhosa injected live in rabbits stimulated the production of 0 antibodies. Sera from these rabbits protected mice against challenge with virulent S. typhosa. Mutation to the dependent state did not result in loss of antigenicity. Streptomycin dependency of the mutant was demonstrated in vivo in the mouse. Antibiotic treated mice succumbed to challenge with dependent bacilli, apparently because of presence of lethal quantities of endotoxin produced by multiplication of the mutant in the presence of streptomycin.


Descriptors :   *ANTIGENS , *SALMONELLA TYPHOSA , STABILITY , ANTIBODIES , LETHAL DOSAGE , STREPTOMYCINS , RABBITS , ENDOTOXINS , INFECTIOUS DISEASES , IN VIVO ANALYSIS


Subject Categories : Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE