Accession Number : AD0432423


Title :   PROTECTION OF MICE AND LAMBS AGAINST PANTROPIC RIFT VALLEY FEVER VIRUS WITH IMMUNE SERUM


Descriptive Note : Technical manuscript


Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD


Personal Author(s) : Bennett, Jr , Dwight G ; Glock, Robert D ; Gerone, Peter J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/432423.pdf


Report Date : Feb 1964


Pagination or Media Count : 17


Abstract : Immune serum was used prophylactically and therapeutically in mice and lambs infected with Rift Valley fever virus. One-tenth milliliter of immune serum was effective in protecting mice against challenge with Rift Valley fever virus for a period of two weeks but not three weeks. A high percentage of mice receiving immune serum within 15 hours after the inoculation of 10 to the 4th power MIPLD(50) of virus were protected. When serotherapy was administered to mice 11 to 25 hours after challenge, pathogenesis was altered so that the usual pantropic nature of the virus was masked and a neurotropic propensity appeared. This was demonstrated by delayed deaths, symptoms involving the central nervous system, and high titers of virus in the brain of the mice. Serotherapy was also effective in one- to three-day-old lambs infected with Rift Valley fever virus. Protection was demonstrated when immune serum was administered after the appearance of viremias and clinical signs of illness. All surviving lambs that received serotherapy were immune to a challenge infection approximately 30 days later.


Descriptors :   *IMMUNE SERUMS , *VIRUSES , MAMMALS , MICE , RIFT VALLEY FEVER VIRUS , LIVER , THERAPY


Subject Categories : Pharmacology
      Microbiology
      Animal Husbandry and Veterinary Medicine


Distribution Statement : APPROVED FOR PUBLIC RELEASE