Accession Number : AD0431827


Title :   EFFECTS OF BICARBONATE ON GROWTH OF PASTEURELLA PESTIS. I. A DIFFERENTIAL RESPONSE OF VIRULENT AND AVIRULENT CELLS


Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD


Personal Author(s) : Surgalla, M J ; Andrews, A W ; Baugh, C L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/431827.pdf


Report Date : Feb 1964


Pagination or Media Count : 16


Abstract : The observation of Delwiche et al that the virulence of broth cultures of Pasteurella pestis aerated at 37 C can be maintained by addition of bicarbonate was confirmed and extended. A differential growth response by virulent and avirulent cells to added bicarbonate under certain conditions was demonstrated. The effect of supplemental bicarbonate on initiation of growth from a virulent inoculum was found to be (a) stimulation of both virulent and avirulent cells at low levels of added bicarbonate, (b) depression of both virulent and avirulent cells at higher initial concentrations, or (c) depression of avirulent mutants with simultaneous stimulation of virulent cells at a narrow range of intermediate levels.


Descriptors :   *GROWTH(PHYSIOLOGY) , *YERSINIA PESTIS , *PASTEURELLA , STIMULATION(PHYSIOLOGY) , BACTERIA , MICROORGANISMS , BICARBONATES


Subject Categories : Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE