Accession Number : AD0431302


Title :   THE MECHANISMS OF INTRARENAL HEMODYNAMIC CHANGES FOLLOWING ACUTE ARTERIAL OCCLUSION,


Corporate Author : CIVIL AEROMEDICAL INST OKLAHOMA CITY OKLA


Personal Author(s) : Hinshaw,Lerner B ; Page,Barbara B ; Brake,CharlesM ; Emerson,Thomas E ,Jr ; Masucci,FrederickD


Report Date : Oct 1963


Pagination or Media Count : 31


Abstract : The hemodynamic response of the kidney to acute arterial occlusion is poorly understood. The purpose of the present study was to determine intrarenal hemodnamic changes in intact and isolated kidneys following arterial occlusion. The relative roles of metabolic, myogenic and tissue pressure influences on the post-occlusion response were evaluated. The response of the kidney to occlusion was found to be complex depending on the interaction of a variety of physical and humoral forces. Increase in renal resistance appeared to be due in part to adrenergic agents and were enhanced by extending time of occlusion and lowering the arterial pressure. The combined effects of pre-venous dilatation and diminished tissue pressure resulted in a decreased resistance following shorter periods of occlusion. Pre-venous dilatation was accounted for by depressed vascular sensitivity to pressor agents and the presence of vasodilator substances. Changes in venous segment resistance were found to be of primary importance in both the autoregulatory phenomenon and the post-occlusion hyperemic response to short (fifteen second) occlusion periods. (Author)


Descriptors :   BLOOD CIRCULATION , KIDNEYS , ARTERIES , OBSTRUCTION(PHYSIOLOGY) , STRESS(PHYSIOLOGY) , SYMPATHOMIMETIC AGENTS , PHYSIOLOGY , BLOOD PRESSURE


Distribution Statement : APPROVED FOR PUBLIC RELEASE