Accession Number : AD0431216


Title :   BIOCHEMICAL AND PHARMACOLOGICAL STUDIES OF L, L-DMETHYLHYDRAZINE.


Descriptive Note : Rep. for 1 June 62-31 May 63,


Corporate Author : OREGON STATE UNIV CORVALLIS


Personal Author(s) : Reed,D J ; Dost,F N ; McCutcheon,R S ; Barbour,R D ; Wang,C H


Report Date : Dec 1963


Pagination or Media Count : 20


Abstract : UDMH at doses of 20, 40 and 60 mg/kg was rapidly metabolized by the rat as evidenced by the metabolism of UDMH-C14 methyl groups to respiratory C14O2. C14 was also rapidly excreted into the urine after administration of UDMH-C14 to the rat. At low levels of UDMH intoxication, the bulk of the compound was either metabolized to respiratory C14O2 or excreted as either UDMH or metabolite(s) in four to six hours after administration. Total hour period after intraperitoneal administration of 40 mg/kg of UDMH. UDMH intoxication of rats at doses of 20, 40 and 60 mg/kg appeared to preferenteally inhibit glucose catabolism to respiratory CO2 via glycolysis and the pentose phosphate pathway. A C-6 decarboxylation process, such as the glucuronate pathway, appeared to be unaffected by UDMH intoxication. (Author)


Descriptors :   ALKANES , BIOCHEMISTRY , PHARMACOLOGY , RATS , CARBON DIOXIDE , URINE , RESPIRATION


Distribution Statement : APPROVED FOR PUBLIC RELEASE