Accession Number : AD0430907


Title :   STUDIES OF THE IMMUNOLOGICAL FACTORS INVOLVED IN HOMOLOGOUS TISSUE TRANSPLANTATION.


Descriptive Note : Annual progress rept., 1 Mar 63-29 Feb 64,


Corporate Author : WESTERN RESERVE UNIV CLEVELAND OHIO SCHOOL OF MEDICINE


Personal Author(s) : Hubay,Charles A


Report Date : 29 Feb 1964


Pagination or Media Count : 137


Abstract : Studies of the association between blood groups and tissue compatibility in the rabbit revealed that antigens controlled by the Hg locus have a significant role in skin graft homograft survival time. A detailed analysis of the problem of chance homogeneity and survival of human homograf transfers is presented. An in vitro assay system is described which can monitor the effects upon antigen-containing bone marrow cells of various sera, lymph node cells and cell-free derivatives of lymph node cells. A cell-free preparation (PTF) from lymph nodes of guinea pigs hypersensitive to chicken egg albumin or bovine gamma globulin was injected into normal animals. Studies were made on the purification of guinea pig transfer factor (PTF). Studies have been made on the subcellular composition of guinea pig lymph node. Various chemical and enzymatic criteria have been employed to define the subcellular fractions obtained by differential ultracentrifugation. (Author)


Descriptors :   TRANSPLANTATION , IMMUNOLOGY , TISSUES(BIOLOGY) , BLOOD GROUPS , ANTIGENS , ANTIBODIES , SKIN(ANATOMY) , SENSITIVITY , SPLEEN , GLUCOSE , LYMPHATIC SYSTEM , TISSUE CULTURE , MICROSOMES , GAMMA GLOBULIN , LABORATORY ANIMALS , RODENTS


Distribution Statement : APPROVED FOR PUBLIC RELEASE