Accession Number : AD0430641


Title :   THE EFFECT OF AGE AT EXPOSURE ON RADIATION-INDUCED POLYDIPSIA IN THE RAT,


Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF


Personal Author(s) : Osborn,G K ; Jones,D C ; Kimeldorf,D J


Report Date : 08 Jan 1964


Pagination or Media Count : 27


Abstract : The effect of age at exposure to a single, sublethal dose of fast neutrons upon acute postirradiation changes in water and food consumption and body weight was studied in young (101 days) and old (619 days) rats. Food consumption (anorexia) and body weight (Loss) responses were similar for the two groups in time (days 1-4 postirradiation) and degree of occurrence. The typical biphasic polydipsia that is observed during the first five days after irradiation of young adult rats was not found in the older animals. Rather, the old rats showed a depressed water consumption with respect to both their own pre-irradiation level and the level of their nonirradiated controls, from the fourth to the eighth days. This depression did not appear to be related to a state of morbidity. (Author)


Descriptors :   *RADIATION EFFECTS , FAST NEUTRONS , AGING(PHYSIOLOGY) , RATS , THIRST , BODY WEIGHT , FOOD , CONSUMPTION , PHYSIOLOGY , RADIOBIOLOGY , WHOLE BODY IRRADIATION


Distribution Statement : APPROVED FOR PUBLIC RELEASE