Accession Number : AD0430367


Title :   IDENTIFICATION AND SIGNIFICANCE OF PAROTID FLUID CORTICOSTEROIDS,


Corporate Author : SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX


Personal Author(s) : Katz,Fred H ; Shannon,Ira L


Report Date : Oct 1963


Pagination or Media Count : 12


Abstract : Parotid fluid, which can be easily collected in continuous fashion, was previously shown to possess free 17-hydroxycorticosteroid (17-OH-CS) levels which paralleled those in serum and reached a maximum two hours after corticotropin or cortisol administration to normal men. The present study demonstrated that intravenously administered cortisol rapidly appeared in the parotid fluid, and that, thus, parotid fluid 17-OH-CS levels would serve as reliable indicators of adrenal function. This was borne out by studies in a patient with Cushing's syndrome as well as in those showing adrenal hyporesponsiveness. Despite the large rise in plasma 17-OH-CS in the third trimester of pregnancy there was only a small, though significant, rise in parotid fluid 17-OH-CS. These data are compatible with the hypothesis that only nonprotein-bound free 17-OH-CS reach the parotid fluid. Conjugated 17-OHCS were not found in appreciable quantity in parotid fluid. Chemical and radioisotopic technics indicated cortisol and cortisone to be the major human parotid fluid 17-OH-CS. (Author)


Descriptors :   *BODY FLUIDS , DOGS , INJECTIONS(MEDICINE)


Distribution Statement : APPROVED FOR PUBLIC RELEASE