Accession Number : AD0430359


Title :   IONIZING IRRADIATION AND ITS EFFECTS UPON HEALING WOUNDS.


Descriptive Note : Annual progress rept., 1 Jan-31 Dec 63,


Corporate Author : RADIATION RESEARCH ASSOCIATES INC FORT WORTH TEX


Personal Author(s) : Reynolds,B L


Report Date : 02 Feb 1964


Pagination or Media Count : 84


Abstract : Radiation injury from exposure of 100 to 1000r in albino rats produces changes in chemical parameters of body tissues which appear to be phasic in character, particularly in striated muscle, lung, arolear connective tissue, and liver. Even in those animals that do not survive exposure to total body irradiation the phasic phenomenon is observed, although reduced in quantity and frequently in quality of the response. Comparison is made to other forms of injury investigated by other observers and our-selves, in which changes in chemical parameters may be seen to behave in like fashion, with the phasic phenomenon. Examinations of striated muscle in animals subjected to total body irradiation allow an appraisal with respect to phasic occurrence, such that gradation of response to the total trauma may be suggested. Suggestions for therapy are based upon the gradation response. A critique of the methodology in sampling, analysis, and interpretation is offered for a more realistic appraisal of this and related work. (Author)


Descriptors :   *RADIATION INJURIES , *BIOCHEMISTRY , PHASE STUDIES , MUSCLES , RATS , TISSUE EXTRACTS , CHEMICAL ANALYSIS , STEROIDS , SURVIVAL(PERSONNEL) , SHOCK(PATHOLOGY) , HEALING


Distribution Statement : APPROVED FOR PUBLIC RELEASE