Accession Number : AD0430236


Title :   A RENAL LESION ASSOCIATED WITH DIURESIS IN THE AGING SPRAGUE-DAWLEY RAT,


Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF


Personal Author(s) : Foley,W A ; Jones,D C ; Osborn,G K ; Kimeldorf,D J


Report Date : 20 Dec 1963


Pagination or Media Count : 37


Abstract : Water balance measurements were combined with a morphologic and histochemical evaluation of selected organs in an attempt to elucidate mechanisms underlying the relatively abrupt increase in water consumption which occurs late in life in an appreciable proportion of male Sprague-Dawley rats. After habituation, food and water consumption, urinary volume and specific gravity, and body weight were measured over a 24-hour period in a metabolism cage. Immediately after the metabolic measurements the animals were sacrificed and the adrenals and kidneys weighed. Histopathologic examinations of pituitary, thyroid, parathyroid, adrenal, kidney and liver tissues were made. Histochemical studies of selected renal enzyme activities were made on all old animals (23 in the high and 24 in the low intake groups) and on an additional group of young animals (1 to 5 months of age) as controls for age effects. No relationship could be established between a variety of histologic lesions detected in endocrine organs and water intake. Special staining for anti-diuretic hormone failed to provide evidence of a diabetes insipidus-like state as the basis of the increased water consumption and diuresis. (Author)


Descriptors :   *RATS , KIDNEY FUNCTION TESTS , AGING(PHYSIOLOGY) , DISEASES , ENZYMES , DIURETICS , PATHOLOGY , METABOLIC DISEASES , MORPHOLOGY(BIOLOGY) , CONSUMPTION , WATER


Distribution Statement : APPROVED FOR PUBLIC RELEASE