Accession Number : AD0429507


Title :   THYROIDAL INFLUENCE ON ALTITUDE TOLERANCE,


Corporate Author : JEFFERSON MEDICAL COLL PHILADELPHIA PA


Personal Author(s) : Debias,Domenic A ; Yen,Wang


Report Date : Dec 1963


Pagination or Media Count : 3


Abstract : Ths investigation aimed at obtaining support for the concept that lesser amounts of cortisol are effective in prolonging the survival time of thyroidectomized rats exposed to altitude because of a decreased catabolism of the steroid in hypothyroid animals. The data indicate that hyperthyroid animals are more susceptible to altitude exposure than are normal animals, and a greater amount of cortisol is required to protect altitude-exposed adrenalectomized animals that have also been thyroidectomized. Increased thyroid function in altitude-exposed animals is indicated by measurements on the following parameters which were increased: thyroidal uptake of I131, release of thyroidal I131, erythrocyte uptake of I131-labeled triiodothyronine. (Author)


Descriptors :   *THYROID GLAND , SURGERY , SURVIVAL(PERSONNEL) , METABOLISM , PHYSIOLOGY , IODINE , ERYTHROCYTES


Distribution Statement : APPROVED FOR PUBLIC RELEASE