Accession Number : AD0429378


Title :   NEW METHODS DEVELOPMENT FOR IRRITANT SCREENING


Descriptive Note : Quarterly progress rept. no. 3, 23 Sep-22 Dec 1963


Corporate Author : BIONETICS RESEARCH LABS INC FALLS CHURCH VA


Personal Author(s) : Hart, E R


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/429378.pdf


Report Date : 10 Jan 1964


Pagination or Media Count : 13


Abstract : Peritoneal mast cells have been found to liberate too small a quantity of histamine to permit evaluation of the activity of irritants. Guinea pig lungs appear suitable. Mice and dogs appear inferior to rabbits for evaluation of eye irritation. Assessment by current methods has now been accomplished on a cumulative total of approximately 280 compounds.


Descriptors :   *HISTAMINE , *IRRITATING AGENTS , METABOLISM , EYE , SKIN(ANATOMY) , PHARMACOLOGY , CHEMICAL COMPOUNDS , LABORATORY ANIMALS


Subject Categories : Chemical, Biological and Radiological Warfare
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE