Accession Number : AD0428177


Title :   ABILITY OF A FISH CELL LINE TO SUPPORT GROWTH OF MAMMALIAN VIRUSES,


Corporate Author : ARMY BIOLOGICAL LABS FREDERICK MD


Personal Author(s) : Officer, Julius E , Jr


Report Date : Dec 1963


Pagination or Media Count : 14


Abstract : A fish cell line derived from rainbow trout gonads (RTG) has been shown to support the proliferation of two arboviruses (Venezualan equine encephalitis (VEE) virus and Eastern equine encephalitis (EEE) virus) at 22 C. EEE virus was more cytopathogenic for RTG cultures than VEE virus, thus making it feasible to distinguish between the two. A persistent infection was obtained with VEE virus for as long as cultures were carried, but not with EEE virus. Both viruses multiplied in chick fibroblast (CF) cells at 22 C to slightly higher titers than in the fish cell line, and both viruses caused a cytopathogenic effect in CF cells. L cells failed to support the growth of either virus at 22 C. (Author)


Descriptors :   *VIRUSES , *CELLS(BIOLOGY) , *MAMMALS , CULTURE , FISHES , CELLS(BIOLOGY) , GROWTH(PHYSIOLOGY) , ENCEPHALITIS , ARBOVIRUSES , BIOASSAY


Distribution Statement : APPROVED FOR PUBLIC RELEASE