Accession Number : AD0427998


Title :   CLINICAL SHOCK; A STUDY OF THE BIOCHEMICAL RESPONSE TO INJURY IN MAN


Descriptive Note : Annual progress rept. 1 Jan-31 Dec 1963


Corporate Author : MARYLAND UNIV BALTIMORE SCHOOL OF MEDICINE


Personal Author(s) : Crowley, R A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/427998.pdf


Report Date : 31 Dec 1963


Pagination or Media Count : 226


Abstract : Traumatic shock is associated usually with severe injury and characterized principally by inability to maintain an adequate circulation. This study focuses on the total problem - the reaction of the body to injury, maintenance of life, and repair of injury. Studies currently in progress and those proposed are aimed primarily to understanding the biochemical response to injury in man. Provisions have been made for careful metabolic studies in the shocked patient without interfering with obvious life saving measures. Such extensive studies have required the assembly of a considerable staff - professional and technical - to support a C.S.U. on a 24-hour basis. Experimental problems relevant to establishment of such a unit evolved from two major factors: (1) original nature of the study (a scientific study of shock in man); and (2) an unprecedented design of this study. Solutions to these problems are described. Since inception of the contract January, 1962, some 200 patients have been studied as they have undergone resuscitation measures. Final organization of the unit now permits more complex studies into the physio-biochemical response to injury in man.


Descriptors :   *ENDOTOXIC SHOCK , BACTERIA , ENZYMES , METABOLISM , AMMONIA , THERAPY , HYPOXIA , PHYSIOLOGY , WOUNDS AND INJURIES , IMMUNOLOGY , CARDIOVASCULAR SYSTEM , HYPOTHERMIA , TOXINS AND ANTITOXINS , HEMORRHAGE , BLOOD COAGULATION


Subject Categories : Stress Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE