Accession Number : AD0427167


Title :   THE IMPLICATION OF TRYPTOPHAN PYRROLASE IN ENDOTOXIN POISONING


Corporate Author : BRYN MAWR COLL PA


Personal Author(s) : Berry, L J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/427167.pdf


Report Date : Sep 1963


Pagination or Media Count : 28


Abstract : An attempt has been made to relate the protective effect of cortisone against lethality of bacterial endotoxins in mice to changes in activity of liver tryptophan pyrrolase (TP), an enzyme known to be activated by the hormone. In mice maintained at 25 C, TP activity remained normal under conditions associated with survival and diminished in activity when animals were not protected. In addition, nicotinamide and diphosphopyridine nucleotide (DPN) were found to protect mice at 25 C against lethality of endotoxin about as effectively as cortisone. At 5 C, however, mice could not be protected against death from endotoxin by DPN and even cortisone and nicotinamide were less effective than at 25 C. Mice in the cold die sooner than and with different symptoms from those at room temperature.


Descriptors :   *BACTERIAL TOXINS , *ENDOTOXINS , HORMONES , ENZYMES , AMIDES , MICE , LETHAL DOSAGE , ORGANIC PHOSPHORUS COMPOUNDS , NUCLEOTIDES , NITROGEN HETEROCYCLIC COMPOUNDS


Subject Categories : Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE