Accession Number : AD0163767


Title :   Meningococcal Polysaccharide Vaccines.


Descriptive Note : Patent,


Corporate Author : OFFICE OF THE SECRETARY OF THE ARMY WASHINGTON D C


Personal Author(s) : Gotschilch,Emil C.


Report Date : 18 JAN 1972


Pagination or Media Count : 8


Abstract : The patent is a process for preparing and isolating antigenic group-specific polysaccharides of serologic group A and group C memingococci used as vaccines. The process employs a cationic substance, such as hexadecyl trimethylammonium bromide, to precipitate the polysaccharide from the whole culture. The antigenic polysaccharides isolated by this process are of high molecular weight (molecular weight 60,000-5,000,000). The main constituent of the antigenic group A polysaccharide is N-acetyl, O-acetyl mannosamine phosphate and the main constituent of the antigenic group C polysaccharide is N-acetyl, O-acetyl neuraminic acid. The two antigenic polysaccharides are useful for producing immunity against meningococcal meningitis in humans.


Descriptors :   (*VACCINES, *NEISSERIA MENINGITIDIS), (*PATENTS, VACCINES), POLYSACCHARIDES, BACTERIA, INFECTIOUS DISEASES, IMMUNITY


Subject Categories : PHARMACOLOGY


Distribution Statement : APPROVED FOR PUBLIC RELEASE