Accession Number : AD0090916


Title :   A Comparison of Toxic Properties of the V-Agents with GB


Descriptive Note : Special rept.


Corporate Author : CHEMICAL CORPS MEDICAL LABS ARMY CHEMICAL CENTER MD


Personal Author(s) : Marzulli, Francis N


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/090916.pdf


Report Date : Dec 1955


Pagination or Media Count : 19


Abstract : Intravenous and percutaneous toxicity dataa obtained using rabbits are analyzed to compare V-agents and GB with respect to inherent toxicity and factors related to percutaneous effectiveness, such as the cumulative percutaneous action of a single application and the rate of percutaneous traversal. The following summarizes the findings of this analysis: 1. Inherent toxicity (LD50 I.V. at 24 hr.) - EA 1517 and GB EA 1511 and EA 1508. 2. Percutaneous toxicity (LD50, decontamination at 24 hr. and at 2 min.). a. 24 hr. - EA 1517 EA 1511 EA 1508 GB. 2 min. - EA 1511 EA 1517 EA 1508 GB. 3. Agent effectiveness (LD50 at 15 min.). a. Inherent - GB and EA 1517 EA 1511 EA 1508. b. Percutaneous - EA 1517 GB EA 1511 EA 1508. 4. Cumulative Percutaneous Action (percut. LD 50 at 15 min. / percut. LD50 at 24 hr.) - EA 1511 EA 1508 EA 1517 GB. 5. Percutaneous Traversal (skin surface to blood stream) (I.V. LD50 / percut. LD50) - a. Percent traversing at 2 min. - EA 1511 EA 1508 EA 1517 GB. b. Percent traversing at 24 hr. - EA 1511 EA 1517 EA 1508 GB. 6. Lethal Conversion factor from 24 hr. to 15 min. (LD50 I.V. at 15 min. / LD50 I.V. at 24 hr.) - GB and EA1517, 1.2; EA 1511, 1.6; EA 1508, 2.6.


Descriptors :   *G AGENTS , *V AGENTS , CHEMICAL WARFARE AGENTS , TOXICITY


Subject Categories : Chemical, Biological and Radiological Warfare


Distribution Statement : APPROVED FOR PUBLIC RELEASE