Accession Number : AD0045973


Title :   TASK 3. ANALOGS OF TETRAHYDROCANNABINAL-POTENTIAL CW AGENTS


Descriptive Note : Bimonthly rept. no. 4, Feb-Mar 1953


Corporate Author : SHELL DEVELOPMENT CO EMERYVILLE CA


Personal Author(s) : WINKLER, D E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/045973.pdf


Report Date : Mar 1953


Pagination or Media Count : 11


Abstract : One of the most active tetrahydrocannabinol analogs mentioned by Adams (Formula I, R=2-nonyl) has been completed. The preparation of the second of Adams' compounds R=1,2-dimethylheptyl) is now at the stage of 2(3,5dimethoxyphenyl)-3-methyloctene-2 and requires four more steps. The preparation of nitrogen and sulfur analogs is being approached by two different methods which were suggested in the previous report. One starting with 3,5-dinitrobenzoic acid has been carried through five steps to 5-methoxy-5-chlorobenzoic acid. The second method which involves the preparation of 3-amino-5-hydroy n-amyl benzene from the corresponding dihydroxy compound has been shown to be feasible. The preparation of 3,5-dibydroxy n-amyl benzene from 3,5-dimethoxyphenyl butyl ketone has presented unexpected difficulties.


Descriptors :   *CHEMICAL WARFARE AGENTS , *CANNABINOLS , PREPARATION , SYNTHESIS(CHEMISTRY) , CHEMICAL ANALOGS


Subject Categories : Pharmacology
      Chemical, Biological and Radiological Warfare


Distribution Statement : APPROVED FOR PUBLIC RELEASE