Accession Number : AD0032228
Title : Inhalation Toxicity of Diborane in Dogs, Rats, and Guinea Pigs
Descriptive Note : Research rept.
Corporate Author : CHEMICAL CORPS MEDICAL LABS ARMY CHEMICAL CENTER MD
Personal Author(s) : Comstock, Charles C ; Feinsilver, Leo
Report Date : 26 Mar 1954
Pagination or Media Count : 21
Abstract : Object. The purpose of this work was to determine the acute and chronic toxicity of diborane by inhalation to dogs, rats, and guinea pigs. Results. 1. Acute exposure. Groups of six rats were exposed to diborane concentrations of 52 to 492 mg/m (expn 3) (47 to 446 ppm) for one to four hours (Ct 10,400 to 37,200 mg min/m (expn 3)). Animals were observed for 14 days after exposure and mortality recorded. Pathological examination of animals dying as a result of gassing was performed. 2. Chronic exposure (6 hours per day, 5 days per week). a. Two dogs and 18 rats were exposed to a diborane concentration of 6 mg/m (expn 3) (5 ppm) for periods of three weeks to six months. Pathological examination of exposed animals was performed. b. Two dogs, 20 rats and 10 guinea pigs were exposed to diborane concentrations of 0.8-1.7 mg/m (expn 3) (1-2 ppm) for periods of one to six months. Pathological examination of exposed animals was performed. Conclusions. 1. Acute exposures. Mortality fractions of 33 to 100% were observed. As the concentration of diborane is raise there is an increasing tendency for deaths of animals to occur at short periods of time after gassing. At the two highest concentrations, 317 and 492 mg/m (expn 3), all animals died within two hours after removal from gassing chamber. 2. Chronic exposures. a. Exposure to 6 mg/m (expn 3) of diborane resulted in death of two dogs after 10 and 25 exposures, respectively. Both dogs developed clinical signs of respiratory infection at about the ninth exposure; this diagnosis was confirmed by autopsy of the first dog. Seventeen of 18 rats died during the course of six months exposure; deaths were distributed between the 7th and 113th exposure. b. One dog died after 14 exposure to 0.8-1.7 mg/m (expn 3) of diborane; the other survived six months of exposure. Pathological examination of the second dog revealed no changes attributable to diborane exposure. None of ten guinea pigs died during 95 exposures. Examination of animals...
Descriptors : *DIBORANES , BORON COMPOUNDS , EXPOSURE(PHYSIOLOGY) , HYDRIDES , INHALATION , LABORATORY ANIMALS , MORTALITY RATE , PATHOLOGY , TOXICITY
Subject Categories : Inorganic Chemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE