Accession Number : AD0015528


Title :   STUDIES ON THE PATHOGENESIS AND IMMUNITY OF TULAREMIA


Descriptive Note : Progress rept. 1 Jan-30 Jun 1953


Corporate Author : KANSAS UNIV LAWRENCE


Personal Author(s) : Downs, Cora M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/015528.pdf


Report Date : 08 Jul 1953


Pagination or Media Count : 51


Abstract : The purified polysaccharide (I) from Bacterium tularense was only slightly immunogenic to 100 LD50 doses of B. tularense in white mice and appeared to enhance the virulence of a partially virulent strain. The relation of Ascoli antigen to I is not understood; both I and the Ascoli antigen sensitized red cells and acted as antigens in precipitin tests and skin tests. The Ascoli antigen, I, and the I-sensitized red cells produced immunity in white rats. A study of killed culture vaccines indicated that smooth strains were more immunogenic than nonsmooth strains. Cells were killed more frequently by ether and Me2CO than by PhOH. Electro-phoresis studies indicated a component in the smooth virulent and avirulent strains which was lacking in the nonsmooth avirulent strains.


Descriptors :   *PATHOGENESIS , *TULAREMIA , *ANTIBODIES , STRAINS(BIOLOGY) , IMMUNITY , VIRULENCE , ERYTHROCYTES , ANTIGENS , CULTURES(BIOLOGY) , VACCINES , SENSITIZING , SKIN TESTS , PURIFICATION , POLYSACCHARIDES , TEST AND EVALUATION , BACTERIA


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE